Obesity Weekend Roundup, January 23, 2015

Obesity Weekend Roundup, January 23, 2015


Obesity Weekend Roundup, January 23, 2015

Posted: 25 Jan 2015 05:00 AM PST

As not everyone may have a chance during the week to read every post, here’s a roundup of last week’s posts:

Have a great Sunday! (or what is left of it)

@DrSharma
Edmonton, AB

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Senja di Tepi Pantai

Senja di Tepi Pantai Cerita Motivasi dan Inspirasi Nomor 1

“Aku menyayangimu seperti halnya, aku menyayangi saudaraku, Ku tak kan Biarkan waktu dan Usia memisahkan persahabatan kita. Ku kan teriakan pada dunia bahwa kau adalah sahabat terbaikku”

Aku masih ingat awal aku bertemu dengan gadis berambut panjang, bermata belo, berbibir tipis dan kulit kuning langsat. Langit berwarna biru bersih, mentari pagi yang menghangatkan badan, kicauan burung yang merdu dan sejuknya alam, Menjadi saksi bisu pertemuan kita. Waktu itu hari kedua aku memasuki Masa Orientasi Siswa di SMP Bunda Citra, saat aku ingin memasuki halaman sekolah aku mendengar teriakan wanita dari seberang jalan SMP Bunda Citra “Hey kamu”, aku merasa teriakan itu tertuju padaku, saat aku menoleh aku melihat seorang gadis sedang mendekatiku di gerbang sekolah yaitu kamu. “Ini” Tiba tiba kau memberiku sebuah dompet berwarna hitam, aku merasa pernah memilikinya!
“Tadi saat kamu turun dari angkutan umum aku melihat dompetmu terjatuh, aku sudah memanggilmu sedari tadi tetapi kau tak menoleh sedikit pun” Jelasnya
“Ohh trimakasih banyak, kau baik sekali, maaf tadi aku tak me
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GLP-1 Analogue Liraglutide For Obesity Gets Positive Vote In Europe

GLP-1 Analogue Liraglutide For Obesity Gets Positive Vote In Europe


GLP-1 Analogue Liraglutide For Obesity Gets Positive Vote In Europe

Posted: 23 Jan 2015 05:00 AM PST

novo_nordiskJust one month after the GLP-1 analogue liraglutide 3 mg received approval for obesity treatment by the US-FDA, liraglutide 3 mg, yesterday, also got a positive nod from the Committee for Medicinal Products for Human Use (CHMP) under the European Medicines Agency (EMA).

Here is how the Novo Nordisk press release describes the mode of action and indication for liraglutide 3 mg:

Saxenda®, the intended brand name of liraglutide 3 mg, is a once-daily glucagon-like peptide-1 (GLP-1) analogue, with 97% homology to naturally occurring human GLP-1, a hormone involved in appetite regulation. The CHMP positive opinion recommends that Saxenda® will be indicated as an adjunct to a reduced-calorie diet and increased physical activity for weight management in adult patients with an initial Body Mass Index (BMI) of >=30 kg/m2 (obese), or >= 27 kg/m² to < 30 kg/m² (overweight) in the presence of at least one weight-related comorbidity such as dysglycaemia (pre-diabetes or type 2 diabetes mellitus), hypertension, dyslipidaemia or obstructive sleep apnoea.”

Regular readers will be aware of the role that the incretin GLP-1 plays in the  regulation of glucose metabolism as well as satiety and appetite.

Data for this approval come from the Phase 3 SCALE trial program involving over 5,000 patients with overweight and obesity, the majority of who also had related comorbidities.

Given that this is an injectable drug that will be available only with a  doctor’s prescription and, as any anti-obesity medication, will need to be used in the long-term, it will be interesting to see how this new approach to obesity treatment will be accepted by doctors and their patients.

Although liraglutide 3 mg may not work for or be tolerated by everyone, I am confident that this much-needed addition to the obesity treatment tool-box will provide a new treatment option to some patients – especially those with obesity related health problems.

@DrSharma
Edmonton, AB

Disclaimer: I have received honoraria for consulting and speaking from Novo Nordisk

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Pregnancy Weight Gain Study

Pregnancy Weight Gain Study


Pregnancy Weight Gain Study

Posted: 22 Jan 2015 05:00 AM PST

Enrich logoToday’s post is for health professionals who provide care to pregnant women in their practice?

Researchers from the University of Alberta are conducting a short online survey to get a better understanding of the barriers and challenges you may experience related to gestational weight gain, and about what may help and support them to help women achieve healthy weights during pregnancy.

The researchers are also asking you to assess the strengths and limitations of the 5As of Healthy Pregnancy Weight Gain, a new resource from the Canadian Obesity Network.

This information will help to inform the development of universal strategies that promote healthy dietary intake and appropriate weight management in pregnancy and postpartum.

Your participation in this short survey is much appreciated.

Click here to take the survey.

@DrSharma
Edmonton, AB

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Activity Trumps Weight Loss For Health?

Activity Trumps Weight Loss For Health?


Activity Trumps Weight Loss For Health?

Posted: 21 Jan 2015 05:00 AM PST

Despite the sharma-obesity-exercise2The fact that it is better to be fit and fat than skinny and unfit is not new – indeed, I would regard the evidence on this as pretty conclusive.

Nevertheless, for those, who still harbour any remaining doubts, the study by Ulf Ekelund on behalf of the EPIC Investigators, recently published in the American Journal of Clinical Nutrition should drive this message home.

This analysis looks at the relationship between physical activity and all-cause mortality in 334,161 European men and women followed for about 12.4 y (corresponding to 4,154,915 person-years).

No matter how the researchers looked at the data, activity levels appeared a better predictor of mortality than BMI or waist circumference.

Thus the authors calculated that while avoiding all inactivity would theoretcally reduce all-cause mortality by 7.35%, trying to maintain a “normal weight” (or rather a BMI less than 30) would reduce mortality by only 3.66% (although avoiding obesity AND inactivity did have the greatest effect).

Despite the limitations of these type of cross-sectional analyses, which as a rule, tend to overestimate the potential benefits of an actual intervention, the message is clear – it appears that even small increases in physical activity in inactive individuals can have substantially greater benefits to health than obsessing about losing a few pounds.

This is indeed useful information, as we have long known that increasing physical activity in most cases does surprisingly little in terms of weight loss but rather a lot in terms of increasing health and fitness.

So do not despair if the hours your patients are putting in at the gym are not changing those numbers on the scale – the health benefits are still worth the effort.

@DrSharma
Reykjavik, Iceland

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